Reversing the Thyroid Hormone Mediated Repression of a HSV-1 Promoter through Computationally Guided Site Directed Mutagenesis
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منابع مشابه
Reversing thyroid-hormone-mediated repression of a HSV-1 promoter via computationally guided mutagenesis.
Thyroid hormones (THs) and their DNA-binding nuclear receptors (TRs) direct transcriptional regulation in diverse ways depending on the host cell environment and specific promoter characteristics of TH-sensitive genes. This study sought to elucidate the impact on transcriptional repression of nucleotide sequence or orientation within TR binding sites - the TH response elements (TREs) of TH-sens...
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